![]() How does the stem cell retain its cellular identity? So understanding how to control this process is critical to understanding related disease. If a cell doesn’t remember what it should be, it can turn into something else, even a malignant cell. During mitosis, transcription is stopped and many chromatin characteristics are lost, which poses a challenge to the continuity of cell identity, especially in fast-circulating stem cells, which require a constant balance between self-renewal and differentiation.
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